Op-Med is a collection of original articles contributed by Doximity members.
Speaker: Anna Di Nardo, MD PhD
How does the skin micobiome interact with the skin cells?
I was presenting how the microbiome that is living on the surface of the skin of everybody is able to control the maturation of these cells and how these cells can discuss between themselves, and with the microbiome, to control the response of the inflammation.
And so it was very interesting the possible application of this similar crossover between the different cells and the different cross talk, because it’s very important in diseases like atopic dermatitis, urticaria, rosacea, in which you have seen that there is an over-expression of inflammation due exactly to microbiome that is not perfectly balanced.
What derm cell biology from your workshop is most important for clinicians?
Knowing how the mast cells can cross talk with fibroblast and how they mature, it’s very important also in the clinical practice because dysbiosis can be a cause of urticaria. While an excess of some kind of bacteria can, for example, be the one that is possible to create rosacea. Now we know that mast cells in rosacea are very important, and without mast cells in the dermis, we would not have the flare-up that patients have every day.